FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PANTOPRAZOLE SODIUM

Objective: The present study was an attempt to develop alternative dosage form for the existing conventional oral, parenteral proton pump inhibitor (PPI) as transdermal patches treating peptic ulcers. Methods: Transdermal of PPI were prepared using HPMC E5 with PVP K 30 and Eudragit L100 polymers in different ratios by a solvent evaporation method. All formulated subjected various evaluation parameters such thickness, folding endurance, weight uniformity, content swelling index, percentage moisture content, uptake, surface pH vitro release studies. Results: exhibited satisfactory characteristics regarding integrity, flexibility, dispersion drug, other quality control parameters. In studies patches, formulation F1 showed prolonged drug (98.99 %) 24 h, which indicates maximum availability skin permeability also that 96.26 % Pantoprazole sodium permeated through rat abdominal h. kinetic carried out it found all formulations follow zero-order mechanism drugs be diffusion rate-limited, Non-Fickian confirmed Korsmeyer–Peppas model. Conclusion: This suggests application holds promised controlled extended period time.